Synthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography
✍ Scribed by Jan Courtyn; Bart Cornelissen; Ruth Oltenfreiter; Marleen Vandecapelle; Guido Slegers; Karel Strijckmans
- Book ID
- 116798735
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 125 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0969-8051
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## Abstract Carbon‐11 labeled __dl‐threo__‐methylphenidate (methyl‐2‐phenyl‐2‐(2‐piperidyl)acetate, Ritalin), a psychostimulant drug widely used to treat attention deficit hyperactivity disorder, was prepared in two steps: O‐methylation of the N‐protected __dl‐threo__‐ritalinic acid derivative with
Dexetimide (Fig. la), a potent muscarinic cholinergic receptor antagonist, and levetimide (Fig. lb), its pharmacologically inactive enantiomer, were labeled with "C for non-invasive in vivo studies of muscarinic cholinergic receptors in the human brain using positron emission tomography. The synthes