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Synthesis of radiotracers for studying muscarinic cholinergic receptors in the living human brain using positron emission tomography: [11C]dexetimide and [11C]levetimide

✍ Scribed by Robert F. Dannals; Bengt Långström; Hayden T. Ravert; Alan A. Wilson; Henry N. Wagner Jr

Publisher
Elsevier Science
Year
1988
Weight
298 KB
Volume
39
Category
Article
ISSN
0883-2889

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✦ Synopsis

Dexetimide (Fig. la), a potent muscarinic cholinergic receptor antagonist, and levetimide (Fig. lb), its pharmacologically inactive enantiomer, were labeled with "C for non-invasive in vivo studies of muscarinic cholinergic receptors in the human brain using positron emission tomography. The syntheses were completed in approximately 32 min using [ct-HC]benzyl iodide as the precursor. The synthesis, purification, characterization and determination of specific activity are presented and discussed.

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