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Stereoselective Synthesis and Biodistribution of Potent [ 11 C]-Labeled Antagonists for Positron Emission Tomography Imaging of Muscarinic Receptors in the Airways

✍ Scribed by Visser, Ton J.; van Waarde, Aren; Jansen, Twan J. H.; Visser, Gerben M.; van der Mark, Thom W.; Kraan, Jan; Ensing, Kees; Vaalburg, Willem

Book ID
126082588
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
290 KB
Volume
40
Category
Article
ISSN
0022-2623

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Dexetimide (Fig. la), a potent muscarinic cholinergic receptor antagonist, and levetimide (Fig. lb), its pharmacologically inactive enantiomer, were labeled with "C for non-invasive in vivo studies of muscarinic cholinergic receptors in the human brain using positron emission tomography. The synthes