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Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4-diones

✍ Scribed by Stanek, Jaroslav; Alder, Alex; Bellus, Daniel; Bhatnagar, Ajay S.; Haeusler, Albert; Schieweck, Klaus


Book ID
121440997
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
738 KB
Volume
34
Category
Article
ISSN
0022-2623

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As part of a study on additions to strained olefins and synthesis of strained nitrogen heterocycles, we have found that addition of methoxycsrbonylnitrene to 1,2dimethylcyclobutene, 2, and l-methylcyclobutene, 2, provides a convenient synthesis of the corresponding 5-azabicyclo[2.l.O]pentanes 2a and