Tactics for the asymmetric preparation of 2-azabicyclo[3.1.0]hexane and 2-azabicyclo[4.1.0]heptane scaffolds
✍ Scribed by Andrzej Wolan; Mohamad Soueidan; Angèle Chiaroni; Pascal Retailleau; Sandrine Py; Yvan Six
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 594 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
As part of a study on additions to strained olefins and synthesis of strained nitrogen heterocycles, we have found that addition of methoxycsrbonylnitrene to 1,2dimethylcyclobutene, 2, and l-methylcyclobutene, 2, provides a convenient synthesis of the corresponding 5-azabicyclo[2.l.O]pentanes 2a and
Several optically active substituted 3-azabicyclo[3.1.0]hexan-2-ones and their thiocarbonyl analogues have been synthesized, and their circular dichroism spectra studied. The crystal structure of thiolactam la showed that the bicyclic skeleton of the title compounds assumes a sofa-like geometry. It