The catalytic enantioselective reduction of prochiral ketones using a chiral thiourea as ligand is reported. Several metallic precursors were tested. e.e.'s up to 94% are obtained with a ruthenium complex.
Synthesis and application of new chiral ligands for the asymmetric borane reduction of prochiral ketones
✍ Scribed by Ron Hulst; Hero Heres; Nathalie C.M.W. Peper; Richard M. Kellogg
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 510 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0957-4166
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
## Abstract A series of novel __N__‐squaramidoacid ligands were prepared conveniently. Without converting to corresponding amino alcohols, these ligands could be used in asymmetric borane reduction of prochiral aromatic ketones to give secondary alcohols in good to excellent enantiomeric excesses.
## Abstract A new __C__~2~‐symmetric chiral catalyst 3,5‐bis[(2__S__)‐(hydroxy‐diphenylmethyl)‐ pyrrolidin‐1‐ylmethyl]‐1,3,4‐oxadiazole was successfully synthesized by the reaction of 2,5‐dichloromethyl‐1,3,4‐oxadiazole with (__S__)‐α,α‐diphenyl‐2‐pyrrolidinemethanol, and applied to the catalytic a
1997 stereochemistry stereochemistry (general, optical resolution) O 0030 30 -032 Chiral Thiourea as Ligand for the Asymmetric Reduction of Prochiral Ketones. -Prochiral ketones are reduced enantioselectively using the chiral thiourea ligand CTU with various metal catalysts. Best yields and selectiv