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Synthesis and Application of [ 18 F]FDG-Maleimidehexyloxime ([ 18 F]FDG-MHO): A [ 18 F]FDG-Based Prosthetic Group for the Chemoselective 18 F-Labeling of Peptides and Proteins †

✍ Scribed by Wuest, Frank; Berndt, Mathias; Bergmann, Ralf; van den Hoff, Joerg; Pietzsch, Jens

Book ID
126334592
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
802 KB
Volume
19
Category
Article
ISSN
1043-1802

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Radiosynthesis and bioconjugation of [18F]FPy5yne, a prosthetic group for the 18F labeling of bioactive peptides
✍ James A. H. Inkster; Brigitte Guérin; Thomas J. Ruth; Michael J. Adam 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 214 KB

## Abstract A new ^18^F‐based prosthetic group has been prepared for the labeling of azide‐modified peptides for use in PET imaging. 2‐[^18^F]fluoro‐3‐(hex‐5‐ynyloxy)pyridine ([^18^F]FPy5yne, [^18^F]‐1) was prepared via efficient nucleophilic heteroaromatic substitution of either the corresponding