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Synthesis and antiviral evaluation of some β-l-2′,3′-dideoxy-5-chloropyrimidine nucleosides and pronucleotides

✍ Scribed by Claire Pierra; Jean-Louis Imbach; Erik De Clercq; Jan Balzarini; Arthur Van Aerschot; Piet Herdewijn; Abdesslem Faraj; Anna G. Loi; Jean-Pierre Sommadossi; Gilles Gosselin


Book ID
114144063
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
215 KB
Volume
45
Category
Article
ISSN
0166-3542

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Synthesis of Potentially Antiviral 2′,3′
✍ Songqing Wang; Junbiao Chang; Shifeng Pan; Kang Zhao 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 German ⚖ 205 KB

## Abstract A series of novel 3′‐(alkyl(hydroxy)amino)‐2′‐fluoronucleoside analogs were prepared __via__ conjugate addition of __N__‐methylhydroxylamine to various 2‐fluorobutenolides. The adducts **13a** and **16** were obtained as single isomers under absolute control of stereochemistry. The cruc