𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and Antiviral Evaluation of 2′,3′-Dideoxy-2′-fluoro-3′- C -hydroxymethyl-β- D -arabinofuranosyl Pyrimidine Nucleosides

✍ Scribed by Hassan, Abdalla E. A.; Pai, Balakrina S.; Lostia, Stefania; Stuyver, Lieven; Otto, Michael J.; Schinazi, Raymond F.; Watanabe, Kyoichi A.

Book ID
126687534
Publisher
Taylor and Francis Group
Year
2003
Tongue
English
Weight
199 KB
Volume
22
Category
Article
ISSN
0732-8311

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis and antiviral evaluation of α-
Synthesis and antiviral evaluation of α-d-2′,3′-didehydro-2′,3′-dideoxy-3′-C-hydroxymethyl nucleosides
✍ Kohei Yamada; Hiroyuki Hayakawa; Shinji Sakata; Noriyuki Ashida; Yuichi Yoshimur 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 427 KB

We have identified a selective S(N)2' reaction triggered by iodide ion that leads to the ring-opening of 2,2'-anhydro-α-nucleosides. By applying the method, we have synthesized α-D-2',3'-didehydro-2',3'-dideoxy-3'-C-hydroxymethyl nucleosides, designed as potential antiviral agents.

Synthesis of Potentially Antiviral 2′,3′
Synthesis of Potentially Antiviral 2′,3′-Dideoxy-2′-fluoro-3′-(hydroxyamino)nucleosides
✍ Songqing Wang; Junbiao Chang; Shifeng Pan; Kang Zhao 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 German ⚖ 205 KB

## Abstract A series of novel 3′‐(alkyl(hydroxy)amino)‐2′‐fluoronucleoside analogs were prepared __via__ conjugate addition of __N__‐methylhydroxylamine to various 2‐fluorobutenolides. The adducts **13a** and **16** were obtained as single isomers under absolute control of stereochemistry. The cruc