## Abstract For Abstract see ChemInform Abstract in Full Text.
Synthesis and antiviral activity of fluoro sugar nucleosides 2: Synthesis and biological evaluations of 2′, 3′-dideoxy-2′-fluoro-3′-C-hydroxymethyl-β-D-arabinofuranosyl nucleosides
✍ Scribed by Moon Woo Chun; Kyung Lee; Yong Suk Choi; Jeewoo Lee; Joong Hyup Kim; Chong Kyo Lee; Bo Gil Choi; Yong Can Xu
- Book ID
- 112961267
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 272 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0253-6269
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## Abstract A series of novel 3′‐(alkyl(hydroxy)amino)‐2′‐fluoronucleoside analogs were prepared __via__ conjugate addition of __N__‐methylhydroxylamine to various 2‐fluorobutenolides. The adducts **13a** and **16** were obtained as single isomers under absolute control of stereochemistry. The cruc
We have identified a selective S(N)2' reaction triggered by iodide ion that leads to the ring-opening of 2,2'-anhydro-α-nucleosides. By applying the method, we have synthesized α-D-2',3'-didehydro-2',3'-dideoxy-3'-C-hydroxymethyl nucleosides, designed as potential antiviral agents.