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Synthesis and antiviral activity of prodrugs of the nucleoside 1-[2′,3′-Dideoxy-3′-C-(hydroxymethyl)-β-d-erythropentofuranosyl] cytosine

✍ Scribed by Scott C. Mauldin; C.J. Paget Jr; C.David Jones; Joseph M. Colacino; Angela J. Baxter; Kirk A. Staschke; Nils-Gunnar Johansson; Lotta Vrang


Book ID
108480631
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
181 KB
Volume
6
Category
Article
ISSN
0968-0896

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Synthesis and antiviral evaluation of α-
✍ Kohei Yamada; Hiroyuki Hayakawa; Shinji Sakata; Noriyuki Ashida; Yuichi Yoshimur 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 427 KB

We have identified a selective S(N)2' reaction triggered by iodide ion that leads to the ring-opening of 2,2'-anhydro-α-nucleosides. By applying the method, we have synthesized α-D-2',3'-didehydro-2',3'-dideoxy-3'-C-hydroxymethyl nucleosides, designed as potential antiviral agents.