Synthesis and antiviral activity of new carbonylphosphonate 2′,3′-dideoxy-3′-thiacytidine conjugates
✍ Scribed by Anne-Sophie Charvet; Fabrice Turin; Philippe Faury; Olivier Hantz; Michel Camplo; Nicolas Mourier; Pascale Berthillon; Jean-Christophe Graciet; Jean-Claude Chermann; Christian Trépo; Jean-Louis Kraus
- Book ID
- 118393426
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 423 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0166-3542
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The synthesis and antiviral evaluation of 2',3'-dideoxy and 2',3'-didehydro-2',3'-dideoxy 4'thionucleosides in both enantiomeric series are described. Enantiomeric 4-O-silylated-4hydroxymethyl-4-thiobutyrolactones, produced in high yield from chiral glycidols, provided suitable chiral synthons: phen