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Synthesis and Antiviral Activity of 2‘-Deoxy-4‘-thio Purine Nucleosides

✍ Scribed by Van Draanen, Nanine A.; Freeman, George A.; Short, Steven A.; Harvey, Robert; Jansen, Robert; Szczech, George; Koszalka, George W.

Book ID
120391358
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
195 KB
Volume
39
Category
Article
ISSN
0022-2623

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Benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-L-threo-pentofuranoside ( ) was used as glycosyl donor for the synthesis of 4Ј-thio-L-threo-pentofuranosyluracil derivatives 23-29. The corresponding cytidine analogue 33 was prepared from 13 via the triazolo derivative 31.