Synthesis and Structural Elucidation of 2′-Deoxy-4′-thio-L-threo-pentofuranosylpyrimidine and -purine Nucleosides

✍ Scribed by Jörn Wirsching; Jürgen Voss; Gunadi Adiwidjaja; Anja Giesler; Jürgen Kopf

• Book ID: 102676669
• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 504 KB
• Volume: 2001
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/1099-0690(200103)2001:6<1077::aid-ejoc1077>3.0.co;2-0

✦ Synopsis

Benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-L-threo-pentofuranoside ( ) was used as glycosyl donor for the synthesis of 4Ј-thio-L-threo-pentofuranosyluracil derivatives 23-29. The corresponding cytidine analogue 33 was prepared from 13 via the triazolo derivative 31.