Synthesis and antitumor activity of inositol phosphotriester analogues
โ Scribed by Song, Fanbo; Zhang, Jing; Zhao, Yuefang; Chen, Wenbin; Li, Luyuan; Xi, Zhen
- Book ID
- 118175874
- Publisher
- Royal Society of Chemistry
- Year
- 2012
- Tongue
- English
- Weight
- 271 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1477-0520
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## Abstract 8,8โDimethylโ5,6,7,8โtetrahydrophenanthreneโ3,4โdione (3) and 8,8โdimethylโ2โ(lโhydroxy ethyl)โ5,6,7,8โtetrahydrophenanthreneโ3,4โdione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active
## Podophyllotoxin aza-analogue 7 (3 RI =H, Rz=Me, H) was designed and synthesized by a highly stereoselective condensation reaction of a cyclic urethane 5 with 3,4,5-trimethoxybenzaldehyde 6 and was found to show a promising in vitro and in vivo antitumor activity. Podophyllotoxin