✦ LIBER ✦

Synthesis and antitumor activity of 7-substituted 20(RS)-camptothecin analogues

✍ Scribed by Sang-sup Jew; Hee-Jin Kim; Myoung Goo Kim; Eun-Young Roh; Youn-sang Cho; Joon-Kyum Kim; Kyung-Hoe Cha; Kang-Keun Lee; Hyun-Jung Han; Jae-Young Choi; Heesoon Lee

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 190 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00131-x

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✦ Synopsis

Novel water-soluble camptothecin analogues with excellent antitumor activity have been designed and synthesized by total synthesis. The analogues were evaluated for cytotoxic activity against five tumor cell lines. The most potent analogue 6e exhibited significant antitumor activity at wider range of doses as compared with camptothecin (T/C 243 % at 70mg/kg; T/C > 150% at 8.75-140mg/kg).

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