Synthesis and antispasmodic activity of 2-alkyl substituted thieno[2,3-d]pyrimidin-4-ones
✍ Scribed by A. P. Mkrtchyan; S. G. Kazaryan; A. S. Noravyan; S. A. Vartanyan; I. A. Dzhagatspanyan; N. E. Akopyan; I. M. Nazaryan
- Book ID
- 112398181
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 297 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0091-150X
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## Abstract magnified image The interaction of both 2‐iminocoumarin‐3‐carbonitriles and 2‐iminocoumarin‐3‐carbothioamides with 2‐aminothiophen‐3‐carboxamides lead to formation of 3‐(4‐oxo‐3,4‐dihydrothieno[2,3‐__d__]pyrimidin‐2‐yl)‐2‐iminocoumarins in two steps. The simplicity of the procedure, as
## Abstract The carbodiimides **4**, obtained from reactions of iminophosphorane **3** with aromatic isocyanates, were reacted with secondary amines to give 2‐dialkylamino‐5‐ethyl‐6‐methyl‐thieno[2,3‐__d__]pyrimidin‐4(3__H__)‐ones **6** in the presence of catalytic amount of EtONa. Reactions of **4