Synthesis and antimalarial activity of 7-benzylamino-1-isoquinolinamines

✍ Scribed by Clare E. Gutteridge; Marshall M. Hoffman; Apurba K. Bhattacharjee; Lucia Gerena

• Book ID: 102339230
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2007
• Tongue: English
• Weight: 309 KB
• Volume: 44
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570440319

✦ Synopsis

Abstract

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Computer modelling suggests that 7‐benzylamino‐1‐isoquinolinamines should mediate antimalarial effects by a mechanism distinct from that employed by existing antimalarial drugs. A series of these compounds was prepared in seven synthetic steps, via reductive amination of 1,7‐isoquinolinediamine. In vitro efficacy testing of the novel compounds against Plasmodium falciparum revealed them to be potent antimalarial agents.