Synthesis, Antimalarial Activity, and Structure–Activity Relationship of 7-(2-Phenoxyethoxy)-4(1 H )-quinolones
✍ Scribed by Cross, R. Matthew; Namelikonda, Niranjan K.; Mutka, Tina S.; Luong, Lisa; Kyle, Dennis E.; Manetsch, Roman
- Book ID
- 118186126
- Publisher
- American Chemical Society
- Year
- 2011
- Tongue
- English
- Weight
- 333 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-2623
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Two sets of tricyclic 1,2,4-trioxanes containing the ABC (10, 11) and ACD ring portions (21, 22, 32, 33, 37, and 38) of artemisinin (1) were synthesized by successive photo-oxygenation of appropriate enol-ether precursors to 1,2-dioxanes and inter-and intramolecular reaction with a carbonyl compound
The three dihydronaphtho[l,2,4]trioxines e l l have been synthesized and two of them converted to the five carbamate and ester derivatives 12-16 (Schemes I and 2). The resulting new trioxanes together with two already known and ascaridole (7) were tested for antimalarial activity against the sensiti