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Synthesis and antiinflammatory activity of novel 12.beta.-substituted analogs of betamethasone

โœ Scribed by Avery, Mitchell A.; Detre, George; Yasuda, Dennis; Chao, Wan Ru; Tanabe, Masato; Crowe, David; Peters, Richard; Chong, Wesley K. M.

Book ID
111901599
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
893 KB
Volume
33
Category
Article
ISSN
0022-2623

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Cinchopen, 2-phenyl-4quinolinecarkxylic acid (I) is one of the early introduced drugs for treatment of gout (1). IX pssesses analgesic, antipyretic, anti-inflarmnato~ am? uricosuric activity (2) -Hmeve.r, the drug is currently notused clinically since it ::as found to produce hepatic damqe (3,4).