Synthesis and analgesic-antiinflammatory activity of certain fluorinated cinchophen analogs

✍ Scribed by Hassan Y. Aboul-Enein

• Publisher: Elsevier Science
• Year: 1991
• Tongue: English
• Weight: 43 KB
• Volume: 54
• Category: Article
• ISSN: 0022-1139
• DOI: 10.1016/s0022-1139(00)83710-0

✦ Synopsis

Cinchopen, 2-phenyl-4quinolinecarkxylic acid (I) is one of the early introduced drugs for treatment of gout (1). IX pssesses analgesic, antipyretic, anti-inflarmnato~ am? uricosuric activity (2) -Hmeve.r, the drug is currently notused clinically since it ::as found to produce hepatic damqe (3,4).