Synthesis and antihypertensive activity of N-(alkyl/alkenyl/aryl)-N′ -heterocyclic ureas and thioureas
✍ Scribed by Opa Vajragupta; Aungkana Pathomsakul; Chutima Matayatsuk; Lek Ruangreangyingyod; Yuvadee Wongkrajang; William O. Foye
- Book ID
- 109388361
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 129 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0022-3549
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Starting from amino(di)azines and 2-chloro-6-methyliso(thio)cyanate a series of aryl-substituted urea and thiourea derivatives was prepared and screened as potential antiepileptics. Among the new derivatives tested, only 2b and 3c exhibited adequate anticonvulsant effects, whereas 3d and 4d were fou
A novel type of diarolyurea compound containing a furan ring has been designed and prepared. Thus, a series of N-aroyl-N@-(5-aryl-2-furoyl)ureas were synthesized by a nucleophilic addition reaction between 5-substituted furamide and aroyl isocyanate in high yield ([80%). Their structures were con-Ðr