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Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

✍ Scribed by Lee, Kyeong ;Ryu, Jung S. ;Jin, Yinglan ;Kim, Woncheol ;Kaur, Navneet ;Chung, Sang J. ;Jeon, Yong-Jin ;Park, Joon-Tae ;Bang, Ji S. ;Lee, Hong S. ;Kim, Tae Y. ;Lee, Jung J. ;Hong, Young-Soo

Book ID
121524188
Publisher
Royal Society of Chemistry
Year
2008
Tongue
English
Weight
256 KB
Volume
6
Category
Article
ISSN
1477-0520

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## Abstract Thiosemicarbazones of __p__‐aminobenzoic acid (PABA) were synthesized and tested for their antimicrobial and anticancer activity. Hydroxamate derivatives **4a–4l** were found to have better antimicrobial and anticancer activity than their acid counterpart. Compound **4d** was found to h