Synthesis and Anticancer Activities of Some Thiazole Derivatives
✍ Scribed by Kayagil, Ismail; Demirayak, Seref
- Book ID
- 120239034
- Publisher
- Taylor and Francis Group
- Year
- 2009
- Tongue
- English
- Weight
- 253 KB
- Volume
- 184
- Category
- Article
- ISSN
- 1042-6507
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📜 SIMILAR VOLUMES
## Abstract A novel series of fourteen substituted selenadiazoles has been synthesized and the compounds tested for their __in vitro__ antiproliferative and cytotoxic activities. The tests were carried out against leukemia (CCRF‐CEM), colon (HT‐29), lung (HTB‐54), and breast (MCF‐7) cancer cells. I
## Abstract The addition of thiosemicarbazones 1 to α‐halo acids 2 is shown to give 2‐hydrazino‐2‐thiazolin‐4‐ones 3 and not 3‐substituted 2‐imino‐3‐(methyleneimino)thiazolidin‐4‐ones 4. The independent synthesis of 2‐thiazolin‐4‐one derivatives 3 is also described.