Synthesis and anti-inflammatory activity of benzophenone analogues
β Scribed by Shaukath A Khanum; Sheena Shashikanth; A.V Deepak
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 434 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0045-2068
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π SIMILAR VOLUMES
A series of acetylenic thiophene derivatives have been synthesized via Pd-catalyzed coupling reaction of 2-(butyltelluro)thiophene with a variety of terminal alkynes. These compounds showed good anti-inflammatory activity in the carrageenininduced paw edema assay on rats.
The role of reactive oxygen species in inflammatory processes has been well documented, while several antioxidant compounds have been shown to exhibit anti-inflammatory activity. We designed novel compounds as potential agents that combine enhanced antioxidant and anti-inflammatory activities. Deriv