New acetylenic furan derivatives: synthesis and anti-inflammatory activity
✍ Scribed by Gilson Zeni; Diogo S Lüdtke; Cristina W Nogueira; Rodrigo B Panatieri; Antonio L Braga; Claudio C Silveira; Hélio A Stefani; Joao B.T Rocha
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 139 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A series of acetylenic thiophene derivatives have been synthesized via Pd-catalyzed coupling reaction of 2-(butyltelluro)thiophene with a variety of terminal alkynes. These compounds showed good anti-inflammatory activity in the carrageenininduced paw edema assay on rats.
A series of ReW sulfamoylthiophene and sulfamoytpyrazole carboxylic acid derivatives was synthesized. Some of these compounds show interesting analgesic properties and significant nonsteroidal anti-inflammatov activities in several models of inflammation.
## Abstract Indomethacin is a non‐steroidal anti‐inflammatory drug but its use is associated with high degree of gastric toxicity therefore it is prescribed only in severe conditions. In order to reduce the gastric toxicity of indomethacin, various oxadiazole, triazole, thiadiazole and triazine der