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Synthesis and Anti-inflammatory Evaluation of New Sulfamoylheterocarboxylic Derivatives

✍ Scribed by Juan A. Díaz; M. Esther Morante; Salvador Vega; Victoriano Darias; Susana Abdala; Laura Delgado; Beatriz de las Heras; Angel Villar; José María Vivas


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
761 KB
Volume
329
Category
Article
ISSN
0365-6233

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✦ Synopsis


A series of ReW sulfamoylthiophene and sulfamoytpyrazole carboxylic acid derivatives was synthesized. Some of these compounds show interesting analgesic properties and significant nonsteroidal anti-inflammatov activities in several models of inflammation.


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The role of reactive oxygen species in inflammatory processes has been well documented, while several antioxidant compounds have been shown to exhibit anti-inflammatory activity. We designed novel compounds as potential agents that combine enhanced antioxidant and anti-inflammatory activities. Deriv