✦ LIBER ✦

Synthesis and anti-inflammatory activity of 3-(benzylideneamino)coumarins in rodents

✍ Scribed by Veeresh Maddi; Kallur S. Raghu; M. N. A. Rao

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 323 KB
Volume: 81
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600810926

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✦ Synopsis

A series of substituted 3-(benzylideneamino) coumarins was synthesized and evaluated for anti-inflammatory activity against carrageenan-induced edema in rats. Halogenated derivatives 4g and 4c, at oral doses of 100 mg/kg, showed 75 and 60% antiedmatous activity, respectively (phenylbutazone antiedematous activity, 58%). The analgesic activity of 4g and 4c, based on inhibition of acetic acid-induced writhing in mice (67 and 62%, respectively, at oral doses of 100 mg/kg) was comparable with that of aspirin (58%). However, these derivatives were devoid of antipyretic activity and showed low activity against adjuvant-induced arthritis.

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