Synthesis, Analgesic and Anti-Inflammatory Activity of 4-(2-Phenoxyphenyl)semicarbazones

✍ Scribed by Ardeshir Rineh; Nosratollah Mahmoodi; Mohammad Abdollahi; Alireza Foroumadi; Maedeh Sorkhi; Abbas Shafiee

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 326 KB
• Volume: 340
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.200700045

✦ Synopsis

Abstract

A series of 4‐(2‐phenoxyphenyl)semicarbazones was synthesized and evaluated for their analgesic and anti‐inflammatory activities. Several compounds (e. g. 10h, 10i, and 11i) were found to be more potent than the reference drug mefenamic acid in the formalin test. Based on the results of an anti‐inflammatory study, 1‐(1‐(2,5‐dimethoxyphenyl)ethylidene)‐4‐(2‐phenoxyphenyl)semicarbazide 11i was the most active compound.