Synthesis and amination of 1-alkyl-6-nitro-4-oxo-7-chloro-1,4-dihydroquinoline-3-carboxylic acids
✍ Scribed by R. G. Glushkov; N. B. Marchanko; I. B. Levshin; L. N. Dronova
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 421 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0091-150X
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The formylation reaction of norfloxacin with __N__,__N__-dimethylformamide (DMF) gives the title compound, C~17~H~18~FN~3~O~4~. In the structure, molecules are connected __via__ weak C—H...O, C—H...π and π–π interactions [perpendicular distance 3.423 Å and centroid–centroid distance 3.8141 Å].
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In the title compound, C 18 H 17 FN 3 O 4 , the piperazinyl ring adopts a chair conformation. The cyclopropyl rings is not coplanar with the quinolone ring system.