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ChemInform Abstract: Synthesis and Amination of 1-Alkyl-6-nitro-4-oxo-7-chloro-1,4- dihydroquinoline-3-carboxylic Acids.

✍ Scribed by R. G. GLUSHKOV; N. B. MARCHENKO; I. B. LEVSHIN; L. N. DRONOVA


Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
28
Category
Article
ISSN
0931-7597

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Synthesis and Exchange Reactions of 5-Alkyl-2-oxo-6-thioxo-1,2,3,6-Tetrahydropyrimidine-4-carboxylic Acids. -The title compounds are prepared as potential dihydroorotase inhibitors. H/D-exchange studies establish a high tendency towards epimerization at C-5. No epimerization is observed under physi