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Synthesis of 7-Bromo-5-iodo-4-oxo-1,4-dihydroquinoline-2-carboxylic acid

โœ Scribed by Filip Dumont; Guido Slegers


Publisher
Wiley (John Wiley & Sons)
Year
2010
Weight
171 KB
Volume
104
Category
Article
ISSN
0037-9646

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Synthesis of [77Br] 5,7-dibromo-4-oxo-1,
โœ F. Dumont; G. Slegers ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 272 KB

The synthesis of [77Br] 5,7-dibromo-4-oxo-1,4-dihydroquinoline-2-carboxylic acid is described. The labelling is performed in order to obtain a tracer for SPECT studies of the Nmethyl-D-aspartate receptor in human brain. Radiosynthesis was carried out using a nonisotopic nucleophilic halogen exchange