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Synthesis and aldose reductase inhibitory activity of new N-(benzyloxy) glycine derivatives

✍ Scribed by Marco Macchia; Silvia Barontini; Adriano Martinelli; Elisabetta Menchini; Susanna Nencetti; Elisabetta Orlandini; Federico Romagnoli


Book ID
114019379
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
550 KB
Volume
53
Category
Article
ISSN
0014-827X

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In vitro aldose reductase inhibitory act
✍ Jack Deruiter; Abram N. Brubaker; Martha A. Garner; Jeffrey M. Barksdale; Charle πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 427 KB

A number of N-benzenesulfonylglycines, alanines, sarcosine, and prolines, which contain the minimum pharmacophore moieties necessary for aldose reductase inhibitory activity, were prepared and tested in the rat lens assay. In this assay, the benzenesulfonylglycines are considerably more potent than