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Synthesis and aldose reductase inhibitory activity of N-(quinolinyl thiocarbonyl) glycine derivatives

✍ Scribed by E Nicolaï; T Güngör; J Goyard; G Cure; A Fouquet; JM Teulon; C Delchambre; A Cloarec


Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
704 KB
Volume
27
Category
Article
ISSN
0223-5234

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In vitro aldose reductase inhibitory act
✍ Jack Deruiter; Abram N. Brubaker; Martha A. Garner; Jeffrey M. Barksdale; Charle 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 427 KB

A number of N-benzenesulfonylglycines, alanines, sarcosine, and prolines, which contain the minimum pharmacophore moieties necessary for aldose reductase inhibitory activity, were prepared and tested in the rat lens assay. In this assay, the benzenesulfonylglycines are considerably more potent than