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Synthesis and aldose reductase inhibitory activity of N-(arylsulfonyl)- and N-(aroyl)-N-(arylmethyloxy)glycines

✍ Scribed by A Balsamo; MS Belfiore; M Macchia; C Martini; S Nencetti; E Orlandini; A Rossello

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
762 KB
Volume
29
Category
Article
ISSN
0223-5234

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In vitro aldose reductase inhibitory act
In vitro aldose reductase inhibitory activity of substituted N-benzenesulfonylglycine derivatives
✍ Jack Deruiter; Abram N. Brubaker; Martha A. Garner; Jeffrey M. Barksdale; Charle πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 427 KB

A number of N-benzenesulfonylglycines, alanines, sarcosine, and prolines, which contain the minimum pharmacophore moieties necessary for aldose reductase inhibitory activity, were prepared and tested in the rat lens assay. In this assay, the benzenesulfonylglycines are considerably more potent than