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Synthesis and Aldose Reductase Inhibitory Activities of Novel O-Substituted Hydroxyphenylacetic Acid Derivatives

โœ Scribed by Dietmar Rakowitz; Helga Angerer; Barbara Matuszczak


Book ID
111698646
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
416 KB
Volume
339
Category
Article
ISSN
0365-6233

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In vitro aldose reductase inhibitory act
โœ Jack Deruiter; Abram N. Brubaker; Martha A. Garner; Jeffrey M. Barksdale; Charle ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 427 KB

A number of N-benzenesulfonylglycines, alanines, sarcosine, and prolines, which contain the minimum pharmacophore moieties necessary for aldose reductase inhibitory activity, were prepared and tested in the rat lens assay. In this assay, the benzenesulfonylglycines are considerably more potent than