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Synthesis and aldose reductase inhibitory activity of substituted 2-oxoquinoline-1-acetic acid derivatives

โœ Scribed by DeRuiter, Jack; Brubaker, Abram N.; Whitmer, William L.; Stein, James L.


Book ID
115456758
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
607 KB
Volume
29
Category
Article
ISSN
0022-2623

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In vitro aldose reductase inhibitory act
โœ Jack Deruiter; Abram N. Brubaker; Martha A. Garner; Jeffrey M. Barksdale; Charle ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 427 KB

A number of N-benzenesulfonylglycines, alanines, sarcosine, and prolines, which contain the minimum pharmacophore moieties necessary for aldose reductase inhibitory activity, were prepared and tested in the rat lens assay. In this assay, the benzenesulfonylglycines are considerably more potent than