✦ LIBER ✦

Synthesis and Absolute Configuration of (−)-Subersic Acid, a Sponge-Derived, Terpenoidal Inhibitor of Human 15-Lipoxygenase

✍ Scribed by Yoshihisa Tanada; Kenji Mori

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 151 KB
Volume: 2003
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.200390128

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

(−)‐Subersic acid (1), a new derivative of p‐hydroxybenzoic acid in which the m‐position is substituted with a bicyclic diterpenoid, was synthesized from (S)‐3‐hydroxy‐2,2‐dimethylcyclohexanone and p‐hydroxybenzoic acid. The stereochemistry of this sponge‐derived inhibitor of human 15‐lipoxygenase was established as (5__R__,10__R__)‐1. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

📜 SIMILAR VOLUMES

Diterpenoid Total Synthesis. Part 33. Sy

Diterpenoid Total Synthesis. Part 33. Synthesis and Absolute Configuration of (-)-Subersic Acid, a Sponge-Derived, Terpenoidal Inhibitor of Human 15-Lipoxygenase.

✍ Yoshihisa Tanada; Kenji Mori 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 5 KB

Biomimetic Synthesis of Marine Sponge Me

Biomimetic Synthesis of Marine Sponge Metabolite Spiculoic Acid A and Establishment of the Absolute Configuration of the Natural Product.

✍ James E. D. Kirkham; Victor Lee; Jack E. Baldwin 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 17 KB 👁 2 views

ChemInform Abstract: Chemoenzymatic Synt

ChemInform Abstract: Chemoenzymatic Synthesis of (+)-Docosa-4,15-dien-1-yn-3-ol, a Component of the Marine Sponge Cribrochalina vasculum, and Confirmation of the Structure and Absolute Configuration of the Acetylenic Alcohol, by Lipase-Catalyzed Biotransformations.

✍ Kiyoshi Morishita; Makoto Kamezawa; Takehiko Ohtani; Hojun Tachibana; Mayumi Kaw 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

Chemoenzymatic Synthesis of (+)-Docosa-4,15-dien-1-yn-3-ol, a Component of the Marine Sponge Cribrochalina vasculum, and Confirmation of the Structure and Absolute Configuration of the Acetylenic Alcohol, by Lipase-Catalyzed Biotransformations. -Via two subsequent lipase-mediated reactions as key s