Diterpenoid Total Synthesis. Part 33. Synthesis and Absolute Configuration of (-)-Subersic Acid, a Sponge-Derived, Terpenoidal Inhibitor of Human 15-Lipoxygenase.

Synthesis and Absolute Configuration of

Synthesis and Absolute Configuration of (−)-Subersic Acid, a Sponge-Derived, Terpenoidal Inhibitor of Human 15-Lipoxygenase

✍ Yoshihisa Tanada; Kenji Mori 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB 👁 1 views

## Abstract (−)‐Subersic acid (**1**), a new derivative of __p__‐hydroxybenzoic acid in which the __m__‐position is substituted with a bicyclic diterpenoid, was synthesized from (__S__)‐3‐hydroxy‐2,2‐dimethylcyclohexanone and __p__‐hydroxybenzoic acid. The stereochemistry of this sponge‐derived inh