ChemInform Abstract: Chemoenzymatic Synthesis of (+)-Docosa-4,15-dien-1-yn-3-ol, a Component of the Marine Sponge Cribrochalina vasculum, and Confirmation of the Structure and Absolute Configuration of the Acetylenic Alcohol, by Lipase-Catalyzed Biotransformations.

✍ Scribed by Kiyoshi Morishita; Makoto Kamezawa; Takehiko Ohtani; Hojun Tachibana; Mayumi Kawase; Midori Kishimoto; Yoshinobu Naoshima

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 34 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199930229

✦ Synopsis

Chemoenzymatic Synthesis of (+)-Docosa-4,15-dien-1-yn-3-ol, a Component of the Marine Sponge Cribrochalina vasculum, and Confirmation of the Structure and Absolute Configuration of the Acetylenic Alcohol, by Lipase-Catalyzed Biotransformations.

-Via two subsequent lipase-mediated reactions as key steps the title compound is synthesized. Additionally, this preparation is also a confirmation of the structure and absolute configuration of the natural product. -(MORISHITA,