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Syntheses, stability, and tumorcidal activity of porphyrin dimers and trimers with ether linkages

โœ Scribed by Ravindra K. Pandey; Fuu-Yau Shiau; Craig J. Medforth; Thomas J. Dougherty; Kevin M. Smith

Book ID
104221817
Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
293 KB
Volume
31
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The first syntheses of a series of regiochemically pure porphyrin dimers and trimers with ether linkages which are structurally related to Photofin@ are described. Stability of these oligomers was investigated using variable temperature proton NiUR spectroscopy, and preliminary biological results reveal that manupulation of peripheral substituents causes a remark-able dfference in photosensitizing ability in vivo.

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