The first syntheses of a series of regiochemically pure porphyrin dimers and trimers with ether linkages which are structurally related to Photofin@ are described. Stability of these oligomers was investigated using variable temperature proton NiUR spectroscopy, and preliminary biological results re
Syntheses of hematoporphyrin dimers and trimers with ether linkages
โ Scribed by Ravindra K. Pandey; Thomas J. Dougherty; Kevin M. Smith
- Book ID
- 104216685
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 274 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
In order to aid in elucidation of the structure of the active components in hematoporphyrin derivative (Hpd), the first syntheses of an ether-linked hematoporphyrin dimer ( 6) and trimer ( 12) are described. After ester hydrolysis, these compounds were positively identified, by comparative HPLC, as components in Photofrin B-II.
๐ SIMILAR VOLUMES
Syntheses and spectroscopic properties of pyropheophorbide-porphyrindimers and a bis-Pyropheophorbide-porphyrin trimeraredescribed.Fluorescence spectroscopic data of theoligomersrevealthat themacrocyclesin thesystemsareonlyweaklycoupled.O 1997 Elsevier ScienceLtd.
## Abstract Oxidative degradation studies of dimeric porphyrins provide valuable information about the individual linkages between the porphyrin units. MS and NMR data of the degradation products of hematoporphyrin derivative furnish unambiguous evidence of ester and ether linkages in the diโ and o