Syntheses of Methylamine-C14 and Diazomethane-C14
✍ Scribed by Jones, A. R.; Skraba, W. J.
- Book ID
- 121145698
- Publisher
- American Association for the Advancement of Science
- Year
- 1953
- Tongue
- English
- Weight
- 269 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0036-8075
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## The synthesis of [ 4-14C]nisoldipine started from dimethyl [ 14C] formamide which was allowed to react with 2-nitrophenyllithium yielding 2-nitro [ 7-14C] benzaldehyde . Knovenagel condensation with isobutyl acetoacetate yielded isobutyl 2-(2-nitr0[7-~~C]benzylidene) acetoacetate. Key reaction
## Abstract The synthesis of Asaley labelled with ^14^C in the mustard (Asaley‐must‐^14^C) or the leucine (Asaley‐leu‐^14^C) moiety is described. In the former, ethyl pamino‐N^α^‐acetyl‐DL‐phenylalanyl‐L‐leucinate was reacted with ethylene oxide(U)‐^14^C to give the bis(hydroxyethyl)amino analogue,
6-14C]Nitrendipine synthesis started from barium[14]carbonate, which was converted to [ 1-14C] acetyl chloride. The acid chloride was condensed with Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione). The resulting intermediate was treated with boiling methanol to give methyl [ 3-14C]acetoacetate.
## Abstract The synthesis of the title compounds [^14^C]‐PMEG (5) and [^14^c]‐EPMG (6) are described. Treatment of [^14^C]guanine with acetic anhydride in 1‐methyl‐2‐pyrrolidinone gave [^14^C]N‐acetylguanine (2). Reaction with 2‐(diethylphosphonomethoxy) ethylmethanesulfonate in N,N‐dimethylformami