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Syntheses of 1-thio-D-xylose and D-ribose esters of diorganoarsinous acids and their anticancer activity

✍ Scribed by Mingzhang Gao; Yiwen Chen; Songde Tan; Joseph H. Reibenspies; Ralph A. Zingaro

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
198 KB
Volume
19
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Several thio‐D‐xylose and D‐ribose esters of dialkylarsinous acids have been synthesized. The crystal structure of 1‐S‐dimethylarsino‐β‐D‐xylopyranose, 7a, has been obtained. Growth inhibition studies of about 60 strains of human cancer cells have been obtained in vitro for compounds 6a, 7a, 13, and 14. The results reveal that these compounds display a strong inhibition to subpanels of leukemia cells in vitro and high selectivity in inhibiting the growth of cancer cells. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:199–206, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20388

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