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Asymmetric Syntheses of l,l- and l,d-Di-myo-inositol-1,1′-phosphate and their Behavior as Stabilizers of Enzyme Activity at Extreme Temperatures

✍ Scribed by Christina M. Longo; Yang Wei; Mary F. Roberts; Scott J. Miller


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
665 KB
Volume
48
Category
Article
ISSN
0044-8249

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Asymmetric Syntheses of l,l- and l,d-Di-
✍ Christina M. Longo; Yang Wei; Mary F. Roberts; Scott J. Miller 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 665 KB

## Abstract **Hitzeschutz**: Die Totalsynthese von l,l‐DIP und l,d‐DIP (siehe Strukturen) beinhaltet als Schlüsselschritt den komplexen Fall einer doppelten asymmetrischen Induktion. Die thermoprotektive Wirkung beider Isomere auf Enzyme wurde untersucht, und beide zeigen biologische Aktivität.magn

Synthesis and biological activities of (
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The synthesis of the (Y and p anomers of the title compound (1) was accomplished from o-mannose. In the key step, the phosphonate analogues of the mannopyranosyl phosphates were prepared by a direct Wadsworth-Emmons condensation of a protected mannose derivative (8) with tetraethyl methylenebisphosp