𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthese von 4, 4′ -Difluorbenzhydryl- [a14C] -1- Piperazin

✍ Scribed by D. Donnert; K. -H. Schweer

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
245 KB
Volume
9
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The synthesis of 4, 4′‐Difluorbenzhydryl‐[a^14^C] ‐1‐piperazin starting with Ba^14^CO~3~is described. The identity of the labelled compound was established by comparison with the unlabelled one, synthesized by the same method. The latter was identified with the aid of elementary analysis, mass‐ and infrared spectroscopy.

📜 SIMILAR VOLUMES

Heterocyclen im Stoffwechsel VIII. Synth
Heterocyclen im Stoffwechsel VIII. Synthese von Lumiflavin-4a-14C und Riboflavin-4a-14C
✍ Korte, Friedhelm ;Ludwig, Gerhard 📂 Article 📅 1958 🏛 Wiley (John Wiley & Sons) ⚖ 333 KB

## Abstract Es werden zwei Mikroverfahren zur Darstellung von Barbitursäure‐5‐^14^C beschrieben. Ausgehend von Natriumcyanoacetat‐2‐^14^C über Malonsäure‐2‐^14^C beträgt die Gesamtausbeute an Barbitursäure‐5‐^14^C 86%, ausgehend von Malonsäurediäthylester‐2‐^14^C 70%. — Die Synthese ringmarkierter

Preparation of 1-methyl-4-[4-(7-chloro-4
Preparation of 1-methyl-4-[4-(7-chloro-4-quinolyl-[3-14C]-amino)benzoyl]piperazine
✍ Theodore S. T. Wang; Rashid A. Fawwaz; Ronald L. Van Heertum 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 292 KB 👁 1 views

1 -M e t h y l -4 -[ 4 -( 7 -c h l o r 0 -4 -q ~n i n o l y l -[ 3 -~~C 1amino)-benzoyllpiperazine (V) was prepared for pharmacokinetic and pharmacodynamic evaluation. The synthesis of V was accomplished first by a modified Claisen ester condensation reaction of diethyl-[2-14C]-malonate, triethyl or

Synthesis of a carbon-14 labeled 1-(indo
Synthesis of a carbon-14 labeled 1-(indole-6-carbonyl-D-phenylglycinyl)-4-(1-methylpiperidin-4-YL)piperazine-[carbonyl-14C], LY517717-[14C], a factor Xa inhibitor
✍ Fengjiun Kuo; Dean K. Clodfelter; Tamara R. Priest; Donald L. K. Kau 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 118 KB

## Abstract Human Factor Xa is a trypsin‐like serine protease, which serves a critical role in blood coagulation events. LY517717 is currently under clinical investigation as a Factor Xa inhibitor. To support the ADME studies, LY517717 was synthesized using D‐phenylglycine with a carbon‐14 labeled

Synthesis of 14C and 3H specifically lab
Synthesis of 14C and 3H specifically labelled 1-benzyl-4- -picolinoyl-piperazine
✍ G. Zólyomi; Z. Budai 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 262 KB

## Abstract Specifically labelled 1‐benzyl‐4‐picolinoyl‐piperazine (**4**) was synthetized for use in metabolism studies. Carbon‐14 was introduced both in benzyl and picolinoyl groups, and tritium in the benzyl group. By using commercial n‐butyllithium in n‐hexane, the yield of picolinic acid was i