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Synthese Et Marquage Au 14C Du N,N Dichloro-2 Ethyl amino-4 Methyl-2 Methoxy-1 Naphtalene Ou Mitoclomine

✍ Scribed by Jean-Claude Madelmont; Marie-France Moreau; Denise Godeneche

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
314 KB
Volume
14
Category
Article
ISSN
0022-2135

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✦ Synopsis

N N , di-2 chloroethyl 4-amino 2-methyl 1-methoxy naphtalen i s labelled with C on two different positions.

-uniformly on the four carbons of the dichloroethyl group by means of radioactive ethylene oxide.

-o n the carbon of the methoxy group by means of radioactive methyl iodide.

14 RESUME

L e N N dichloro-2 ethyl amino-4 mkthyl-2 mkthoxy-1 naphtal'ene e s t marque en deux positions.

uniformkment s u r l e s q u a t r e carbones du groupement dichloroi t h y l e B p a r t i r d e l'oxyde d'6thyl'ene radioactif.

s u r l e carbone du groupement mkthoxy B p a r t i r d e l ' i o d u r e d e mkthyle radioactif. La mitoclomine e s t une moutarde B l'aeote dont la s t r u c t u r e p o r t e u s e e s t t r k s proche d'une substance naturelle la vitarnine K C ' e s t GRANGER (1) qui en 1966 a propose la f o r m u l e d e c e nouvel agent cytotoxique. 5' 0362-4003/lS/Q214-Q281801.00/0 01978 by John Wiley & Sons Ltd. B p a r t i r du mkthyl-2, o( naphtol selon l e processus indiquk dans l e schema 2.

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