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Synthese Du Methyl-2 Dinitro-4,6 Phenol (Noyau 14C-U) (DNOC, DINOC NOYAU 14C-U)

✍ Scribed by J. P. Noël; L. Pichat

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
304 KB
Volume
17
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

SYNTHESIS OF 2‐METHYL‐4,6 DINITRO PHENOL (RING U‐^14^C) (DNOC, DINOC ring U‐^14^C)

O‐methoxymethylphenol (ring U‐^14^C) 3 Was prepared in 82 % yieltd from phenol (ring U‐^14^C) and methylal in presence of p‐toluene sulfonic acid and molecular sieve. Ortholithiation of 3 with n Buli + TMEDA in hexane offorded a lithioderivative 4 which was methylated with methyl iodide in ether ‐ hexane. Deprotection of phenol group lead to o ‐ cresol (ring U‐^14^C) : 6 purified on a silicagal column with a 52% yield based on 3. Nitration of 6 provided DNOC (ring U‐^14^C) with a 28% overall yield from phenol (ring U‐^14^C) ‐ Specific activity was: 70 mCi/mMole.

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