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Synthese de tris-(dimethylamino-2,4,6) triazine-1,3,5 14C-2-4-6 (hexamethylmelamine (noyau) 14C-2-4-6), un nouvel agent antitumoral

✍ Scribed by Nguyen-Hoang-Nam; Henri Hoellinger; Louis Pichat

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
211 KB
Volume
12
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

L'hexaméthylmélamine (noyau) ^14^C‐2‐4‐6 (HMM ^14^C), un nouvel agent antitumoral, a été synthétisée à partir de l'urée ^14^C en 2 stades. L'urée ^14^C est cyclisée dans l'o‐dichlorobenzène en acide cyanurique ^14^C‐2‐4‐6, purifié par chromatographie sur colonne d'échangeur d'ions Séphadex SP C‐25. L'amination directe de l'acide en présence de HMPT et de diméthylamine donne l'HMM ^14^C. Aprés purification par chromatographie sur colonne de gel de silice d'adsorption, on obtient. l'HMM ^14^C avec un rendement radioactif global de 18 % par rapport à l'urée ^14^C, activité spécifique : 32 mCi/mMole.

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