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Synthese de la pentamethylmelamine (noyau 14C-4,6), un nouvel agent antitumoral

✍ Scribed by Do-cao-thang; Nguyen-hoang-nam; H. Hoellinger; L. Pichat

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
234 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

(ring‐4,6‐^14^C) Pentamethylmelamine (^14^C‐PMM), a new antitumor agent, was prepared from barium (^14^C) carbonate by a 6 step synthesis. (^14^CN) Dimethylcyanamide, prepared from sodium (^14^C) cyanide with 71% yield and treated with phosgene in the presence of hydrogen chloride, was cyclized to (ring‐4,6‐^14^C)‐2‐chloro‐4,6‐bis (dimethylamino)‐s‐triazine. The latter was purified by silicagel low pressure liquid chromatography (15% yield based on nitrile) and condensed with monomethylamine to give ^14^C‐PMM. After purification ^14^C‐PMM was obtained with 91% yield, specific activity = 38 mCi/mMole. The mechanism of the reaction of nitrile with phosgene was discussed.

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